PDK2: An Underappreciated Regulator of Liver Metabolism

Autogynephilia: an underappreciated paraphilia.

Autogynephilia is defined as a male's propensity to be sexually aroused by the thought of himself as a female. It is the paraphilia that is theorized to underlie transvestism and some forms of male-to-female (MtF) transsexualism. Autogynephilia encompasses sexual arousal with cross-dressing and cross-gender expression that does not involve women's clothing per se. The concept of autogynephilia ...

Altered Atrial Metabolism: An Underappreciated Contributor to the Initiation and Progression of Atrial Fibrillation

A trial fibrillation (AF) is the most common cardiac arrhythmia and is associated with increased morbidity and mortality. Currently, about 1% to 2% of the general population suffers from AF. The incidence and prevalence of AF increase in an age-dependent manner, resulting in a projected AF-prevalence in the United States in 2050 of 16 millions. It is assumed that between a quarter and two-third...

Alcoholism and Catatonia: An Underappreciated Relationship

Catatonia is a complex neuropsychiatric syndrome that has been described in medical literature since the 16th century [1]. Lifethreatening complications involving every organ system can ensue, signaling high levels of associated morbidity and mortality [2]. To this day, little is known about the etiology of catatonia [3]. Catatonia occurs most frequently in patients with affective disorders and...

GLP1, an Important Regulator of Intestinal Lipid Metabolism.

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.

Alpha-ketoglutarate is a key metabolic intermediate at the crossroads of carbon and nitrogen metabolism, whose fate is tightly regulated. In mycobacteria the protein GarA regulates the tricarboxylic acid cycle and glutamate synthesis by direct binding and regulation of three enzymes that use α-ketoglutarate. GarA, in turn, is thought to be regulated via phosphorylation by protein kinase G and o...